A 74-year-old postmenopausal woman presents with progressive height loss, chronic back pain, and recent vertebral compression fractures. DEXA scan shows a T-score of −3.2. What is the most important underlying mechanism of her condition?
A
Excessive osteoblastic bone formation
B
Increased osteoclastic bone resorption
C
Defective collagen synthesis
D
Calcium over-deposition in bone